Yes you can block duplicate click on the campaign level. So multiple clicks from per user will land only one time based on your defined time period.
To enable this, go to a particular Campaign > Setting > Basic
In Basic, you will find an option for Duplicate Click Action.
Unique click will be checked based on cookies droped on user browser and session duration you have set.
You can set Click Duration In hours and define what should happen with duplicate clicks, It should Redirect to Blank Page or Any Fallback URL.